2025

Mahameed M, Xue S, Danuser B, Hamri GC, Xie M, Fussenegger M. Nitroglycerin-responsive gene switch for the on-demand production of therapeutic proteins. Nat Biomed Eng. 2025.

 

2022

Mahameed M, Xue S, Stefanov BA, Hamri GC, Fussenegger M. Engineering a Rapid Insulin Release System Controlled By Oral Drug Administration. Adv Sci (Weinh). 2022;9(9):e2105619.

 

Mahameed M, Wang P, Xue S, Fussenegger M. Engineering receptors in the secretory pathway for orthogonal signalling control. Nat Commun. 2022;13(1):7350.

 

Mahameed M, Fussenegger M. Engineering autonomous closed-loop designer cells for disease therapy. iScience. 2022;25(3):103834.

 

Darawshi O, Muz B, Naamat SG, Praveen B, Mahameed M, Goldberg K, et al. An mTORC1 to HRI signaling axis promotes cytotoxicity of proteasome inhibitors in multiple myeloma. Cell Death Dis. 2022;13(11):969.

 

Boukeileh S, Darawshi O, Shmuel M, Mahameed M, Wilhelm T, Dipta P, et al. Endoplasmic Reticulum Homeostasis Regulates TLR4 Expression and Signaling in Mast Cells. Int J Mol Sci. 2022;23(19).

 

Obiedat A, Charpak-Amikam Y, Tai-Schmiedel J, Seidel E, Mahameed M, Avril T, et al. The integrated stress response promotes B7H6 expression. J Mol Med (Berl). 2020;98(1):135-48.

 

2020

Mahameed M, Boukeileh S, Obiedat A, Darawshi O, Dipta P, Rimon A, et al. Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy. Nat Commun. 2020;11(1):1304.

 

Forno F, Maatuf Y, Boukeileh S, Dipta P, Mahameed M, Darawshi O, et al. Aripiprazole Cytotoxicity Coincides with Activation of the Unfolded Protein Response in Human Hepatic Cells. J Pharmacol Exp Ther. 2020;374(3):452-61.

 

2019

Weiss-Sadan T, Itzhak G, Kaschani F, Yu Z, Mahameed M, Anaki A, et al. Cathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth and Proliferation. Mol Cell Proteomics. 2019;18(7):1330-44.

 

Obiedat A, Seidel E, Mahameed M, Berhani O, Tsukerman P, Voutetakis K, et al. Transcription of the NKG2D ligand MICA is suppressed by the IRE1/XBP1 pathway of the unfolded protein response through the regulation of E2F1. Faseb j. 2019;33(3):3481-95.

 

Mahameed M, Wilhelm T, Darawshi O, Obiedat A, Tommy WS, Chintha C, et al. The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors. Cell Death Dis. 2019;10(4):300.

 

Mahameed M, Sulieman A, Alkam D, Tirosh B. Towards Enhancing Therapeutic Glycoprotein Bioproduction: Interventions in the PI3K/AKT/mTOR Pathway. Cell Struct Funct. 2019;44(2):75-83.

 

Mahameed M, Obiedat A, Beck G, Johnson JC, Tirosh B. Low concentrations of cadmium chloride promotes protein translation and improve cell line productivity. Biotechnol Bioeng. 2019;116(3):569-80.

 

2017

Mahameed M, Tirosh B. Engineering CHO cells with an oncogenic KIT improves cells growth, resilience to stress, and productivity. Biotechnol Bioeng. 2017;114(11):2560-70.

 

Lankri D, Albarghouti G, Mahameed M, Tsvelikhovsky D. Multifaceted α-Enaminone: Adaptable Building Block for Synthesis of Heterocyclic Scaffolds Through Conceptually Distinct 1,2-, 1,3-, 1,4-, and C-O Bond Forming Annulations. J Org Chem. 2017;82(14):7101-13.